Everton’s U23 side will face West Ham at the Merseyrail Community Stadium on Monday evening in Premier League 2 action, 7pm kick off.
The game kicks off at 7pm and is free entry for Southport and Everton Season ticket holders.
Tickets are available on turnstiles for £5 adults, £3 concessions.
Everton are due to play the “mini-derby” against Liverpool on 16th April at the Merseyrail Community Stadium.